Data request
Summary statistics or raw data from the following studies can be requested.
Science 2019: Genomic map
We analyzed genetic data of 47,429 MS and 68,374 control subjects and established a reference map of the genetic architecture of MS. This map includes 32 variants within the extended Major Histocompatibility Complex (MHC), 200 autosomal susceptibility variants outside the MHC, and one chromosome X variant.
Cell 2018: Low-frequency variants
We showed in 68,379 cases and controls that up to 5% of MS risk heritability is explained by low-frequency variation in gene coding sequence. We identified three novel genes driving MS risk independently of common-variant signals, highlighting key pathogenic roles for regulatory T cell homeostasis and regulation, IFNγ biology, and NFκB signaling.
Nature Genetics 2013: ImmunoChip
Using the ImmunoChip custom genotyping array and combining these data with previous GWAS data, we identified 48 new susceptibility variants, leading to 1150 established MS risk variants at 103 discrete loci outside the major histocompatibility complex.